Figure 1.

Flowchart of endovascular treatment procedures. The strategy of intra-arterial TNK administration in this study was composed of two steps. The first step was an infusion of 4  mg TNK after the microcatheter navigation across the clot. Then, a stent retriever device was deployed through the microcatheter from distal to proximal across the site of occlusion. The second step was an infusion of intra-arterial TNK (0.4  mg/min) continuously for 20 min after the first retrieval attempt. A DSA was performed to determine the status of the occluded vessel. If successful reperfusion was not achieved, subsequent passes were performed according to standard procedure.