Table 3.
BRETIS-TNK group (n = 26) | Control group (n = 26) | Unadjusted | Adjusted | |||
---|---|---|---|---|---|---|
Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value | |||
Primary outcome | ||||||
First-pass successful reperfusion (n, %) | 14 (53.8) | 6 (23.1) | 3.89 (1.18–12.84) | 0.03 | 3.95 (1.17–13.35) | 0.03* |
Secondary outcomes | ||||||
mRS (0–2) at 90 days (n, %) | 13 (50.0) | 9 (34.6) | 1.89 (0.62–5.76) | 0.26 | 1.99 (0.60–6.57) | 0.26* |
ENI | 9 (34.6) | 6 (23.1) | 1.77 (0.52–5.97) | 0.36 | 1.89 (0.54–6.56) | 0.32* |
Safety outcome | ||||||
sICH (n, %) | 2 (7.7) | 2 (7.7) | 1.00 (0.13–7.69) | 1.00 | 2.362 (0.16–35.47) | 0.53* |
Other outcomes | ||||||
Final successful reperfusion (n, %) | 21 (80.8) | 19 (73.1) | 1.55 (0.42–5.70) | 0.51 | 1.61 (0.43–6.12) | 0.48* |
mRS at 90 days, median (IQR) | 2.5 (2, 4) | 3.5 (1, 5) | 0.58 | |||
Any ICH (n, %) | 8 (30.8) | 7 (26.9) | 1.21 (0.36–4.01) | 0.76 | 1.26 (0.37–4.33) | 0.71* |
HI-1 | 1 (3.8) | 0 (0.0) | ||||
HI-2 | 0 (0.0) | 1 (3.8) | ||||
PH-1 | 1 (3.8) | 0 (0.0) | ||||
PH-2 | 6 (23.1) | 6 (23.1) | ||||
PHr-1 | 0 (0.0) | 0 (0.0) | ||||
PHr-2 | 0 (0.0) | 0 (0.0) | ||||
Death within 90d (n, %) | 5 (19.2) | 5 (19.2) | 1 (0.25–3.97) | 1.00 | 1.34 (0.28–6.36) | 0.71* |
mRS, modified Rankin Scale; ENI, early neurological improvement; sICH, symptomatic intracerebral hemorrhage; ICH, intracerebral hemorrhage; HI, hemorrhagic infarct; PH, parenchymal hemorrhage; PHr, remote parenchymal hemorrhage. *Adjusted for key prognostic covariates (NIHSS at admission and ORT).