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. 2023 Apr 18;14:1178337. doi: 10.3389/fimmu.2023.1178337

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Copyright © 2023 Chaintreuil, Kerreneur, Bourgoin, Savy, Favreau, Robert, Jacquel and Auberger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophage polarization. Monocyte-derived-macrophages can be polarized ex vivo and in vivo into pro- or anti-inflammatory macrophages in response to different stimuli. Pro-inflammatory macrophages are involved in the anti-microbial and anti-tumor response and are implicated in the evolution of several pathologies such as atherosclerosis or type 2 diabetes. Anti-inflammatory macrophages exhibit an immunosuppressive activity, are involved in tissue repair, and promote angiogenesis. They are also involved in the evolution of various pathologies including fibrosis and tumor progression.