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. 2023 Apr 18;14:1155552. doi: 10.3389/fimmu.2023.1155552

Figure 1.

Figure 1

Effect of antigen type on GMT for in-house and FLUCOP HAI testing for [1A] A viruses and [1B] B viruses. A shared human serum panel was tested in 10 laboratories with three antigenically similar viruses from each seasonal influenza subtype/lineage –egg propagated reassortant viruses (Egg Reas), egg isolated and propagated WT viruses (Egg WT) and cell isolated and propagated WT viruses (Cell WT). Viruses were tested by HAI using in-house testing (In-H) with in-house antigens or using a FLUCOP consensus protocol and common source viruses (FLUCOP). The difference is represented as the fold difference in GMT of in-house/FLUCOP testing. The red dashed line indicates a fold change of 1 i.e. where in-house and FLUCOP testing gave the same GMT. Fold differences higher than 1 indicate titres are higher using in-house testing, and fold differences of less than 1 indicate titres are lower using in-house testing. Overall GMTs across the serum panel for each condition and laboratory are shown in figure S1 .