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. 2023 Apr 21;16(4):dmm049942. doi: 10.1242/dmm.049942

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Sleep is regulated by trbl levels in the fat body. (A) Schematic representation of the Drosophila TriKinetics activity monitoring system. (B) Expression of trbl does not alter the activity of flies while they are awake (NS, not significant; unpaired t-test). (C) Analysis of circadian patterns of flies upon upregulation or downregulation of trbl. (D) trbl levels in the fat body regulate night-time sleep. Effects of trbl expression or RNAi on total sleep duration during 24 h (left; ***P<0.001, ****P<0.0001; unpaired t-test), during the day (middle; NS, not significant; **P<0.01; unpaired t-test) and during the night (right; ****P<0.0001; Mann–Whitney test) are shown. The analysis was carried out in 14-day-old male flies. Genotypes: in B-D, w; pplGal4/+; + (control), w; pplGal4/UAStrbl-HA; + (UAS-trbl), w; pplGal4/UAS trblRNAi; + (UAS-trbl-RNAi).