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. 2023 Apr 21;16(4):dmm049942. doi: 10.1242/dmm.049942

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Higher TRIB mRNA levels are linked to the inverse relationship between weight and sleep duration. (A) The rs2980874 (G) variant in TRIB1 is significantly associated with a higher WHR and shorter sleep duration [scaled estimate (95% confidence intervals); *P<0.05, ****P<0.0001; linear regression). The causal estimate of the effect of WHR on sleep is calculated by dividing its gene–outcome association by its gene–exposure association [estimate (95% confidence intervals); *P<0.05, Wald test]. Red and blue correspond respectively to positive and negative associations, respectively. (B) Mendelian randomisation analysis of all significant genetic instruments for WHR and their effect on sleep duration [estimate (95% confidence intervals); *P<0.05; weighted median and inverse variance weighted]. (C) Mendelian randomisation analysis of TRIB2 variants correlated with increased mRNA levels, and their effect on weight (BMI) or sleep duration [estimate (95% confidence intervals); *P<0.05, Wald test]. The SNP instrument used for increased TRIB2 mRNA and weight is rs17390839 (A). The SNP instrument used for increased TRIB2 mRNA and sleep duration is rs72773697 (A).