Table 1.

Baseline demographics and disease characteristics

Characteristic	Overall (N=51)	Cohort 1 (n=3)	Cohort 2 (n=3)	Cohort 3 (n=3)	Cohort 4 (n=9)	Cohort 5 (n=10)	Cohort 6 (n=9)	Cohort 7A (n=14)
Median age, years (min, max)	59 (22, 83)	67 (56, 76)	55 (43, 66)	58 (56, 83)	67 (22, 79)	57 (38, 75)	52 (42, 62)	62 (41, 78)
Male, n (%)	33 (64.7)	2 (66.7)	3 (100)	2 (66.7)	7 (77.8)	6 (60.0)	7 (77.8)	6 (42.9)
Tumor type, n (%)
CRC	45 (88.2)	3 (100)	3 (100)	3 (100)	7 (77.8)	8 (80.0)	7 (77.8)	14 (100)
SCCHN	6 (11.8)	0	0	0	2 (22.2)	2 (20.0)	2 (22.2)	0
Time since first cytological or histopathological diagnosis (years), median (min, max)	2.6 (0.4, 9.8)	2.4 (0.6, 5.2)	2.4 (1.6, 3.9)	3.7 (1.0, 6.0)	2.4 (1.5, 9.8)	3.9 (1.0, 8.4)	2.4 (0.4, 9.8)	2.5 (1.2, 8.0)
Time since first metastatic disease diagnosis (years), median (min, max)	n=49 2.4 (0.1, 9.8)	n=3 2.4 (0.6, 3.2)	n=3 1.6 (0.9, 3.9)	n=3 3.7 (1.9, 6.0)	n=8 2.3 (0.1, 9.8)	n=10 3.2 (1.0, 5.0)	n=9 2.4 (0.4, 4.3)	n=13 2.3 (0.3, 8.0)
Tumor stage at baseline, n (%)
IIA	2 (3.9)	0	0	1 (33.3)	1 (11.1)	0	0	0
IIIB	1 (2.0)	0	0	0	0	0	0	1 (7.1)
IIIC	1 (2.0)	0	0	0	0	0	0	1 (7.1)
IVA	19 (37.3)	2 (66.7)	2 (66.7)	0	4 (44.4)	5 (50.0)	2 (22.2)	4 (28.6)
IVB	27 (52.9)	0	1 (33.3)	2 (66.7)	4 (44.4)	5 (50.0)	7 (77.8)	8 (57.1)
Unknown	1 (2.0)	1 (33.3)	0	0	0	0	0	0
No of prior systemic regimens, n (%)
1	6 (11.8)	1 (33.3)	0	1 (33.3)	2 (22.2)	1 (10.0)	1 (11.1)	0
2	12 (23.5)	0	1 (33.3)	0	2 (22.2)	3 (30.0)	3 (33.3)	3 (21.4)
3	7 (13.7)	0	1 (33.3)	0	3 (33.3)	0	2 (22.2)	1 (7.1)
4	9 (17.6)	0	1 (33.3)	0	1 (11.1)	1 (10.0)	2 (22.2)	4 (28.6)
5	7 (13.7)	1 (33.3)	0	1 (33.3)	0	3 (30.0)	1 (11.1)	1 (7.1)
>5	10 (19.6)	1 (33.3)	0	1 (33.3)	1 (11.1)	2 (20.0)	0	5 (35.7)

Patient numbers provided for characteristic for which not all patients had data available.

CRC, colorectal cancer; SCCHN, squamous cell cancer of the head and neck.