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. 2023 Apr 18;14:1096565. doi: 10.3389/fimmu.2023.1096565

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Copyright © 2023 Min, Na, Jhun, Lee, Choi, Park, Lee, Um, Lee, Seo, Shin, Kim, Lee, Kwok, Cho and Park

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of gut microbiomes between axial spondyloarthritis (axSpA) patients and healthy controls (HCs). Feces were obtained from axSpA patients (N = 33) and HCs (N = 20), and 16s rRNA was analyzed using next generation sequencing. (A) α-diversity measured by observed OTUs and Chao1 score and (B) β-diversity using PCoA based on Bray-Curtis dissimilarity between axSpA patients (N = 33) and HCs (N = 20). Pearson’s correlation (r) and the corresponding P values are presented. Relative abundance of gut microbes in axSpA patients and HCs according to genus (C, D), and species levels (E, F). Species-level gut microbes that were significantly different between groups are presented. OTUs, operational taxonomic units; PCoA, principal coordinate analysis.