Table 3.

Univariate and multivariate analysis of risk factors for mortality after cholangiocarcinoma recurrence.

	Univariate		Multivariate
	p	HR (IC 95%)	p	HR (IC 95%)
Sex (Female)	0.884	1.03(0.66-1.62)
Age (>= 65 years)	0.716	1.08(0.69-1.68)
T (T3-4)	0.795	1.06(0.67-1.69)
N +	0.675	1.11(0.69-1.77)
M +	0.219	1.63(0.74-3.57)
R status (ref R0) - R1 - R2	0.542 0.419 0.512	1.23(0.75-2.01) 0,62(0.15-2.59)
Adjuvant CHT (yes)	0.006	0.51(0.31-0.82)	0.013	0.52(0.31-0.87)
Time to recurrence < 1 year	0.013	1.76(1.13-2.74)	0.001	2.22(1.39-3.54)
Recurrence Treatment: CHT or Surgery VS Supportive Care	<0.001	0.35(0.21-0.58)	<0.001	0.34(0.20-0.58)

CHT, Chemotherapy.