Fig. 3.

Categorization of neurons. A) All neurons. A total of 209 neurons were isolated across DC3 and DC4. Unresponsive neurons did not show a significant response to any of the cues (22%); 57% of neurons showed a significant excitation to at least one cue, followed by 14% showing significant inhibition, and 7% showing mixed excitation and inhibition responses depending on the cue. B) Cue-specific neurons. A total of 64 neurons were selective to 1 cue specifically, with either a significant excitation (exc) or inhibition (inh). Neurons showing excitation to only the fear + safety cue (FS) made up the largest subpopulation (41%). C) Cue-overlapping neurons; 78 neurons showed a similar excitation (exc) or inhibition (inh) to >1 cue. Neurons showing excitation to the fear + safety cue and reward cue (FS/R) made up the largest subpopulation (36%). D) Bidirectional neurons; 8 neurons showed opposing responses to the fear + safety versus fear cues. Most of these showed an excitation to the fear + safety cue and inhibition to the fear cue (FS exc & F inh).