TABLE 1.
Additive effects of cathepsin G and BPI in inhibiting the growth of H. capsulatum yeastsa
| Concn (μg/ml) of:
|
% Inhibition of growthb | |
|---|---|---|
| Cathepsin G | BPI | |
| 0.1 | 13.4 ± 4.6 | |
| 0.5 | 14.6 ± 2.1 | |
| 1.0 | 23.3 ± 7.4 | |
| 0.1 | 0.5 | 39.0 ± 8.1 |
| 0.1 | 1.0 | 43.4 ± 5.8 |
H. capsulatum yeasts (5 × 103) were incubated with cathepsin G, BPI, or both for 24 h at 37°C. The yeasts then were pulsed with [3H]leucine for an additional 24 h to quantitate the growth of the remaining viable yeasts.
Mean ± SEM; n = 4.