. 2023 Jan 1;10(1):8–11. doi: 10.5152/eurjrheum.2022.22028
Content of this journal is licensed under a Table 2.
Description of Serious Infections
| Sex | Disease | Age at First Infection (Years) | Therapies Before TCZ | Infections Before TCZ (n) | TCZ Regimen | Time Since TCZ Start (Months) | Time Since Last TCZ (Days) | GC Dose (mg/day) | Infections | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Site | Micro organism | CRP (mg/L) | Outcomes | |||||||||
| Ma | Unclassified vasculitis | 82 | GC, ANA, MTX, AZA, DIS | 3 | IV | 16 | 12 | 5 | ORL | No | 140 | Healing |
| 24 | 6 | 9 | Urinary | E. coli | 161 | Healing | ||||||
| 31 | 28 | 15 | Pulmonary | No | 331 | Healing | ||||||
| 34 | 23 | 15 | Skin | No | 340 | Healing | ||||||
| 37 | 76 | 15 | Skin | No | 187 | Healing | ||||||
| M | GCA | 75 | GC, ANA | 0 | SC | 5 | 4 | 20 | Pulmonary | No | 368 | Healing |
| M | Castelman | 88 | No | 0 | IV | 1 | 9 | 0 | Digestive (diverticulitis) | No | 36 | Healing |
| F | Relapsing polychondritis | 73 | GC, DIS, MTX, AZA | 1 | IV | 3 | 5 | 30 | Skin | VZV | NA | Post-zosterian pain |
| F | GCA | 66 | GC, MTX | 1 | SC | 3 | 7 | 12 | Digestive (oesophagitis) | Candida | 2 | Healing |
| 15 | 4 | 2 | Skin | VZV | <1 | Post-zosterian pain | ||||||
| Mb | GCA | 65 | GC, MTX | 3 | IV | 1 | 13 | 50 | Skin | E. cloacae | NA | Skin wound |
| 3 | 8 | 30 | Skin | E. coli | 61 | Skin wound | ||||||
| 3 | 21 | 30 | Bacteriemia | P. aeruginosa | NA | Healing | ||||||
| 6 | 117 | 8 | Pulmonary | HRSV, E. cloacae | 126 | Healing | ||||||
| 7 | 160 | 6 | Skin | P. aeruginosa, S. aureus, S. pyogenes | 47 | Healing | ||||||
aHad non-substituted hypogammaglobulinemia;
bHad substituted hypogammaglobulinemia.
M, male; F, female; GCA, giant cell arteritis; TCZ, tocilizumab; GC, glucocorticoids; ANA, anakinra; MTX, methotrexate; AZA, azathioprine; DIS, disulone; IV, intravenous; SC, subcutaneous; E. coli, Escherichia coli; VZV, varicella zoster virus; E. cloacae, Enterobacter cloacae; P. aeruginosa, Pseudomonas aeruginosa; HRSV, human respiratory syncytial virus; S. aureus, Staphylococcus aureus; S. pyogenes, Streptococcus pyogenes; CRP, C-reactive protein; NA, not available.