. 2023 Mar 15;38(5):938–950. doi: 10.1093/humrep/dead050

Table III.

Comparison of the global evolution of the characteristics of the patients between the beginning of the pregnancy and the third trimester.

	N	PCOS N = 30	N	Control N = 29	P	P interaction
Total AMH (pmol/l)						0.007
T0	30	35.1 [22.9–53.7]^a	29	10.7 [6.8–16.8]^a	<0.001^a
T1	29	30.0 [23.5–38.2]^a	29	11.2 [8.4–14.9]^a	<0.001^a
T2	28	30.8 [23.7–39.9]^a	28	12.2 [8.9–16.7]^a	<0.001^a
T3	26	28.9 [17.4–47.8]^a	27	11.2 [6.7–18.8]^a	<0.001^a
Cleaved AMH (pmol/l)						0.019
T0	14	23.7 [13.8–40.6]^a	24	6.8 [3.9–11.9]^a	<0.001^a
T1	26	19.0 [13.9–25.8]^a	29	7.1 [5.0–10.0]^a	<0.001^a
T2	28	18.5 [14.2–24.1]^a	28	7.1 [5.2–9.7]^a	<0.001^a
T3	25	16.2 [9.4–27.8]^a	27	6.1 [3.5–10.4]^a	<0.001^a
LH (IU/l)						0.85
T0	28	1.95 [0.15–24.74]^a	17	1.19 [0.09–15.28]^a	0.026 ^a
T1	29	0.34 [0.09–1.22]^a	29	0.25 [0.07–0.88]^a	0.90^a
T2	28	0.03 [0.01–0.09]^a	28	0.01 [0.00–0.06]^a	0.51^a
T3	26	0.08 [0.00–1.33]^a	27	0.05 [0.00–0.71]^a	1.00^a
Total T, TT (ng/ml)						0.58
T0	27	0.43 [0.27–0.67]^a	16	0.33 [0.20–0.53]^a	0.10^a
T1	29	0.87 [0.67–1.15]^a	29	0.69 [0.51–0.93]^a	0.28^a
T2	28	0.79 [0.64–1.00]^a	28	0.53 [0.41–0.70]^a	0.017 ^a
T3	26	0.76 [0.47–1.23]^a	27	0.50 [0.32–0.81]^a	0.034 ^a
SHBG (nmol/l)						0.29
T0	8	150.5 [−8.1–309.3]	5	163.9 [5.5–322.4]	1.00
T1	24	250.0 [155.3–344.7]	29	289.6 [196.4–382.8]	0.37
T2	28	381.0 [339.3–422.7]	28	381.8 [336.5–427.2]	1.00
T3	25	399.2 [274.7–523.7]	25	416.2 [294.3–538.0]	1.00
DHEAS (µmol/l)						<0.001
T0	8	3.35 [1.43–5.29]	5	2.79 [0.82–4.77]	1.00
T1	24	3.53 [2.21–4.86]	29	3.93 [2.55–5.33]	1.00
T2	28	3.42 [2.71–4.13]	28	3.34 [2.45–4.23]	1.00
T3	25	3.63 [2.25–5.03]	25	3.57 [2.11–5.03]	1.00
Androstenedione (ng/ml)						0.20
T0	27	1.19 [0.66–2.15]^a	16	0.91 [0.49–1.70]^a	0.26^a
T1	27	2.14 [1.52–3.03]^a	28	1.94 [1.35–2.79]^a	1.00^a
T2	28	2.13 [1.65–2.77]^a	28	1.48 [1.11–1.98]^a	0.054^a
T3	25	2.37 [1.29–4.36]^a	27	1.47 [0.81–2.67]^a	0.025 ^a

Values are presented as mean [CI 95%] adjusted. Values and P-values were adjusted for pre-specified confounding factors, namely age at the beginning of pregnancy, BMI at the beginning of pregnancy, week of gestation at each sampling time, and conception method (i.e. spontaneous, ovulation induction (OI) or ART). P values for each time were corrected by Bonferroni. P-values in bold refer to statistically significant values. ^aCalculated after log-transformation. NA: not applicable; P: P-value; N: number of available observations; T0: before pregnancy; T1: first trimester of pregnancy; T2: second trimester of pregnancy; T3: third trimester of pregnancy; AMH: anti-Müllerian hormone; PCOS: polycystic ovary syndrome; Cleaved AMH: (total AMH − proAMH Measurement); SHBG: sex hormone-binding globulin; DHEAS: dehydroepiandrosterone sulfate.