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. 2023 May 2;10(2):020601. doi: 10.1117/1.NPh.10.2.020601

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© 2023 The Authors

Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Fig. 5 — Representative applications of LSI in rodents. (a) Representative data showing that a 23-month-old AD (3xTg) mouse has lower baseline CBF (left) and impaired NVC response (right and bottom) compared with an age-matched control mouse. (b) Visualization of CBF in the penumbra after MCAO induced focal ischemia in aged (top row) and young (middle row) rats, and time trace comparisons (bottom row) (adapted from Ref. 181). (c) Asphyxial cardiac arrest followed by CPR reveals distinct overall and pulsatile CBF phases throughout a cardiac arrest and resuscitation experiment (baseline, cardiac arrest, hyperemia, and hypoperfusion). (d) A TREM2 agonist, COG1410, improved CBF (top and bottom left) and mitigated BBB breakdown (top and bottom right) following CCI-induced TBI (adapted from Ref. 182).