Fig. 6.

Representative applications of SFDI in rodents. (a) ${\mu }_a$ (top, left), ${\mu }_s^{\prime }$ (top, right), and hemoglobin concentrations (bottom) are altered in 3xTg AD mice by 8 months of age (adapted from Ref. 210). (b) The onset of focal ischemia reveals alterations in hemodynamic properties of $C_{\mathrm{HbO}2}$, $C_{\mathrm{HbR}}$, $C_{\mathrm{HbT}}$, and ${\mathrm{StO}}_2$ (adapted from Ref. 211). (c) Asphyxial cardiac arrest followed by CPR reveals distinct changes in ${\mathrm{StO}}_2$ and scattering in different phases of a cardiac arrest and resuscitation experiment (baseline, cardiac arrest, hyperemia, and hypoperfusion) (adapted from Ref. 76). (d) TBI-induced changes in $C_{\mathrm{HbO}2}$, $C_{\mathrm{HbR}}$, and ${\mathrm{StO}}_2$ but not $C_{\mathrm{HbT}}$ (adapted from Ref. 212).