Figure 3.

Curve fitting examples showing each of the four most distinct trajectories in smartphone walking function. Each graph encompasses all s2MWT data of a single patient. The upper panels show the s2MWT scores (circles), the LLTM fit (solid line), and its 95% CI (band). Statistically significant change in the estimated s2MWT occurs when there is no overlap in 95% CIs between different time points (shown as dashed arrows). The middle panels show the T25FW scores (dots) with 20% thresholds for clinically relevant change (horizontal bars). Similarly, the lower panels show the EDSS scores with its thresholds for clinically relevant change: 1.5 points if EDSS = 0, 1 point if EDSS between 1.0 and 5.5, or 0.5 points if EDSS ⩾ 6.0. Occurrences of a relevant change in clinical outcomes are denoted by asterisks.

Abbreviations: T25FW: timed 25-foot walk test; EDSS: Expanded Disability Status Scale; s2MWT: smartphone-based 2-minute walk test; LLTM: local linear trend model.