Table 1.

. Characteristics of the included patients and their association with the S_intra/immune, S_intra/cancer, and S_intra/tissue.

Characteristics	Categories	Total N (%)	S intra/immune P value	S intra/cancer P value	S intra/tissue P value
Histology (N = 935)	LUSC	462 (49.41%)	0.011	0.057	0.49
	LUAD	473 (50.59%)
Age (N = 934)	≥65	566 (60.6%)	0.61	0.38	0.38
	<65	368 (39.4%)
Sex (N = 935)	female	377 (40.32%)	0.03	0.016	0.21
	male	558 (59.68%)
Smoking history (N = 903)	current reformed smoker for ⇐ 15 years	394 (43.63%)	0.36	0.17	0.32
	current reformed smoker for > 15 years	199 (22.04%)
	current smoker	230 (25.47%)
	lifelong nonsmoker	80 (8.86%)
Pack years (N = 723)	≥35	478 (66.11%)	0.23	0.12	0.20
	<35	245 (33.89%)
TMB (N = 902)	<3	347 (38.47%)	0.26	0.31	0.65
	≥3	555 (61.53%)
Stage (N = 935)	ia	214 (22.89%)	0.075	0.31	0.20
	ib	257 (27.49%)
	iia	114 (12.19%)
	iib	159 (17.01%)
	iiia	129 (13.80%)
	iv	62 (6.63%)