Table 2. Risk of Parkinson Disease According to Rheumatoid Arthritis (RA) Status and Serologic Status of RA.
| No. | Event, No. | Duration, person-y | Incidence rate (per 1000 person-y) | HR (95% CI)a | ||||
|---|---|---|---|---|---|---|---|---|
| Crude | Model 1 | Model 2 | Model 3 | |||||
| By RA status | ||||||||
| Control | 273 400 | 803 | 1237 781.0 | 0.65 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| RA | 54 680 | 290 | 243 582.6 | 1.19 | 1.84 (1.61-2.10) | 1.89 (1.65-2.16) | 1.87 (1.63-2.14) | 1.74 (1.52-1.99) |
| By RA status and seropositivity | ||||||||
| Control | 273 400 | 803 | 1 237 781.0 | 0.65 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| SNRA | 15 670 | 56 | 68 804.0 | 0.81 | 1.26 (0.96-1.65) | 1.34 (1.02-1.75) | 1.31 (1.00-1.71) | 1.20 (0.91-1.57) |
| SPRA | 39 010 | 234 | 174 778.6 | 1.34 | 2.07 (1.79-2.39) | 2.10 (1.81-2.43) | 2.09 (1.80-2.41) | 1.95 (1.68-2.26) |
| By seropositivity | ||||||||
| SNRA | 15 670 | 56 | 68 804.0 | 0.81 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| SPRA | 39 010 | 234 | 174 778.6 | 1.34 | 1.65 (1.23-2.21) | 1.56 (1.16-2.09) | 1.59 (1.19-2.14) | 1.61 (1.20-2.16) |
Abbreviations: HR, hazard ratio; SNRA, seronegative rheumatoid arthritis; SPRA, seropositive rheumatoid arthritis.
a
Model 1 was adjusted for age, sex, smoking, alcohol drinking, physical activity, low income, and body mass index; model 2 was adjusted additionally for diabetes, hypertension, hyperlipidemia, and chronic kidney disease; and model 3 was adjusted additionally for myocardial infarction, stroke, and depression.