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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Nat Methods. 2023 Mar 23;20(4):559–568. doi: 10.1038/s41592-023-01799-x

Fig. 2.

Fig. 2.

Performance evaluation on synthetic data. a. Precision, recall, and F1 score in DEL, DUP, and INV calling and genotyping at 30x genome coverage. b. FN calls broken down by size, SV type, and genome context. The following number of simulated SVs were assigned to each genome context: SD=1,131(8.3%), SR=786 (5.8%), RM=8,722 (64.6%), and unique=2,865 (21.2%). c. Recall of two complex SV types (INVDUP and INVDEL) at 60x genome coverage. Bottom: Cue image channels for an example of each event type found only by Cue. d. Recall of subclonal somatic SVs broken down by type at 60x genome coverage. All panels: paired-end Illumina short reads were simulated from the corresponding synthetic genome using DWGSIM [35] and mapped with BWA-MEM [36].