TABLE 2.

Genetic analysis (DAVID) of investigated significant genes

DAVID symbol	DAVID name	Results	Functions
Up-regulated genes
P2RX2	Purinergic receptor P2X 2	Up-regulated in OAB	Nuclear inner membrane Intrinsic component of nuclear inner membrane Ligand-gated cation channel activity Nucleotide receptor activity Ligand-gated channel activity
SMTN	Smoothelin	Up-regulated in OAB	Smooth muscle contraction Contractile fiber Actin-mediated cell contraction Actin filament-based movement Actin-myosin filament sliding
GAP43	Growth-associated protein 43	Up-regulated in OAB	Transmitter-gated ion channel activity Extracellular ligand-gated ion channel activity Neuron projection organization Neurotransmitter receptor activity Modulation of chemical synaptic transmission
TRPM8	Transient receptor potential cation channel subfamily M member 8	Up-regulated in OAB	Calcium ion transport Calcium ion transmembrane transporter activity Divalent inorganic cation transmembrane transporter Antimicrobial humoral response Ligand-gated cation channel activity
CDH11	Cadherin 11	Up-regulated in OAB	Cell-cell junction organization Extrinsic component of membrane Cell-cell junction Banded collagen fibril Complex of collagen trimers
GJC1	Gap junction protein gamma 1	Up-regulated in OAB	Regulation of heart contraction Regulation of blood circulation Cell-cell signaling involved in cardiac conduction Cardiac muscle cell contraction sinoatrial node cell to atrial cardiac muscle cell communication
CHRM2	Cholinergic receptor muscarinic 2	Up-regulated in OAB	Acetylcholine receptor signaling pathway Cellular response to acetylcholine Adenylate cyclase-inhibiting G protein—coupled receptor signaling pathway Postsynaptic signal transduction Serotonin receptor activity
CHRM3	Cholinergic receptor muscarinic 2	Up-regulated in OAB	Serotonin receptor activity G protein—coupled amine receptor activity Acetylcholine receptor signaling pathway Cellular response to acetylcholine Adenylate cyclase-inhibiting G protein
TRPV4	Transient receptor potential cation channel subfamily V member 4	Down-regulated in OAB	Regulation of cytosolic calcium ion concentration Voltage-gated potassium channel activity Cellular calcium ion homeostasis Protein autophosphorylation Inorganic cations import across plasma membrane
Down-regulated genes
P2RX3	Purinergic receptor P2X 3	Down-regulated in OAB	Nuclear inner membrane Intrinsic component of nuclear inner membrane Nucleotide receptor activity Excitatory extracellular ligand-gated ion channel activity Extracellular ligand-gated ion channel activity
P2RX5	Purinergic receptor P2X 5	Down-regulated in OAB	Extracellular ligand-gated ion channel activity Calcium ion transport into cytosol Cytosolic calcium ion transport Positive regulation of cytosolic calcium ion Response to purine-containing compound

DAVID, Database for Annotation, Visualization, and Integrated Discovery; OAB, overactive bladder.