Table 1.
Overall and Age-Specific Distribution of Cervical High-Risk HPV Infection and Cervical Cytopathology Restricted to WWH With Anal HSIL+ and Anal HPV16-Positive HSIL+
| Overall n (%) |
15–34 Years n (%) |
35–44 Years n (%) |
≥45 Years n (%) |
|
|---|---|---|---|---|
| Anal HSIL+a | N = 115 | N = 28 | N = 47 | N = 40 |
| Cervical HR-HPV Infection | ||||
| Negative | 64 (56%) | 16 (57%) | 24 (51%) | 24 (60%) |
| Positive | 51 (44%) | 12 (43%) | 23 (49%) | 16 (40%) |
| Non-16 HR-HPV only | 40 (35%) | 10 (36%) | 19 (40%) | 11 (28%) |
| HPV16 | 11 (9%) | 2 (7%) | 4 (9%) | 5 (12%) |
| Cervical Cytopathology | ||||
| Normal | 65 (57%) | 14 (50%) | 24 (51%) | 27 (68%) |
| LSIL | 42 (36%) | 13 (46%) | 18 (38%) | 11 (27%) |
| HSIL+ | 8 (7%) | 1 (4%) | 5 (11%) | 2 (5%) |
| HPV16-positive anal HSIL+b | N = 48 | N = 12 | N = 17 | N = 19 |
| Cervical HR-HPV Infection | ||||
| Negative | 21 (44%) | 5 (42%) | 5 (29%) | 11 (58%) |
| Positive | 27 (56%) | 7 (58%) | 12 (71%) | 8 (42%) |
| Non-16 HR-HPV only | 19 (39%) | 6 (50%) | 9 (53%) | 4 (21%) |
| HPV16 | 8 (17%) | 1 (8%) | 3 (18%) | 4 (21%) |
| Cervical Cytopathology | ||||
| Normal | 33 (69%) | 9 (75%) | 10 (59%) | 14 (74%) |
| LSIL | 10 (21%) | 2 (17%) | 5 (29%) | 3 (16%) |
| HSIL+ | 5 (10%) | 1 (8%) | 2 (12%) | 2 (10%) |
Abbreviations: HIV, human immunodeficiency virus; HR-HPV, high-risk human papillomavirus; HSIL+, high-grade squamous intraepithelial lesions or worse; WWH, women with HIV.
The overall prevalence of anal HSIL+ in women with HIV was 6% (115 of 1852). Prevalence was 6% (28 of 466) at age 15–34 years, 7% (47 of 713) at age 35–44 years, and 6% (40 of 673) at age ≥45 years.
HPV16-positive anal HSIL+ includes only HSIL+ with simultaneous presence of HPV16 positivity in swabs; overall prevalence of HPV16-positive anal HSIL+ in women with HIV was 3% (48 of 1852); prevalence was 3% (12 of 466) at age15–34 years, 2% (17 of 713) at age 35–44 years, and 3% (19 of 673) at age ≥45 years.