Table 3.
Univariable and Multivariable Analysis of Response to Neoadjuvant Chemoradiation (Using Binary Logistic Regression)
| Characteristics | Response-group 1 a, e | Response-group 2 b, e | Response-group 3 c, e | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Uni | Multi | Uni | Multi | Uni | Multi | ||||
| P | P | OR | P | P | OR | P | P | OR | |
| Age | 0.7 | - | - | 0.66 | - | - | 0.06 | 0.96 | 1.002 |
| Sex (M vs. F) | 0.64 | - | - | 0.29 | - | - | 0.27 | - | - |
| Clinical tumor stage | 0.31 | - | - | 0.34 | - | - | 0.19 | 1.0g | 0.00g |
| 0.12h | 0.22h | ||||||||
| Clinical nodal status (N+ve vs. N-ve) | 0.74 | - | - | 0.23f | - | - | 0.61 | - | - |
| Distance from AV | 0.48 | - | - | 0.65 | - | - | 0.94 | - | - |
| Pretherapy NLR d | 0.70 | - | - | 0.66 | - | - | 0.16 | 0.82 | 1.08 |
Abbreviations: AV, anal verge; NLR, neutrophil-to-lymphocyte ratio, OR, odds ratio; TRG, tumor regression grade; a, GR (TRG 0-1), PR (TRG 2-3); b, pCR (TRG 0), non-pCR (TRG 1-3); c, responsive (TRG 0-2), non-responsive (TRG 3); d, The cutoff is the median value for response-groups 1 and 2 and based on receiver operating characteristic (ROC) analysis for response-groups 3; e, Based on American Joint Committee on Cancer (AJCC) 8th edition; f, Not entered to multivariable analysis due to single significant variable in the univariable analysis; g, T3 vs. T2; h, T4 vs. T3