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Ubiquitin linkage types and their roles. Ubiquitination can occur as single or multiple monoubiquitin or as homotypic/heterotypic/branched chains linked through K6, K11, K27, K29, K33, K48, or K63, as well as M1. The functional consequences of ubiquitin signals are determined by cellular and substrate‐context, ubiquitin chain position, linkage type and conformation, ranging from proteasomal degradation to nonproteolytic functions.
