TABLE 4.
The enzymatic specificities of different writers and erasers.
| Acylations from SCFAs | Writers | Erasers |
|---|---|---|
| Propionylation | GCN5, 485 PCAF, 486 P300/CBP, 472 MYST (MOF, MOZ, HBO1), 487 KAT6A 488 | SIRT1, SIRT2, SIRT3, SIRT5 489 |
| Butyrylation | p300, 472 , 490 P300/CBP, 472 GNAT 491 | SIRT3, 492 SIRT5, 493 |
| Malonylation | NA | SIRT3, 493 SIRT2, SIRT5 494 |
| Succinylation | KAT2A 495 | SIRT5, 483 SIRT7 484 |
| 2‐Hydroxyisobutyrylation | P300, 487 Tip60, EP300 496 | SIRT5, 497 HDAC2, 496 HDAC3 498 |
| β‐Hydroxybutyrylation | P300/CBP, MYST, GNAT 499 | HDAC1, HDAC2, SIRT1–3 500 |
| Crotonylation | P300/CBP, 501 GNAT, MYST, 502 HBO1, KAT6A, MOF, PCAF, TIP60 503 | SIRT1–3, HDAC1–3, HDAC8 502 |
| Glutarylation | P300, 479 KAT2A 504 | SIRT5, 477 , 483 SIRT7 505 |
| Lactylation | p300 480 | HDAC1–3 506 |