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. 2023 Apr 18;10:1130174. doi: 10.3389/fcvm.2023.1130174

Table 2.

List of major studies reporting results of catheter ablation of ventricular arrhythmias in patients with MVP.

References Author Sample Size Age (years) Female (%) Valvular abnormality (%) Type of arrhythmia Common ablation site Acute success (%) Mean Follow-up (months) Follow-up Results
(44) Syed et al 14 33.8 93 Bileaflet MVP with mild MR NSVT or sustained VT (57%)
History of cardiac arrest, ICD shocks for PVC-triggered VF (43%)
Papillary muscle/fascicular
sites (93%)
Both LV papillary muscles (55%)
Purkinje system (79%)
86 25 Significant decrease in VT burden and appropriate ICD shocks
(41) Lee et al 9 58.0 78 Bileaflet MVP (89%)
< moderate MR (67%)
NSVT (56%) PPM (48%)
Both LV papillary muscles (26%)
60 41 VT recurrences for 25%*
(40) Bumgarner et al 30 54.3 53 Bileaflet MVP (52%)
Posterior MVP (36%)
≥ moderate MR (72%)
PVC (44%)
Sustained VT (39%)
Papillary muscle (27%)
MV annulus (15%)
67 30 VA recurrences for 26%
(42) Enriquez et al 25 54.7 64 Bileaflet MVP (72%)
Mild to moderate MR (76%)
PVC and NSVT (56%) PPM (56%)
Antero-lateral papillary muscle (32%)
76 31 20% → 6% reduction in PVC burden
(45) Ezzeddine et al 40 47.0 70 MAD PVC, sustained VT and PVC-triggered VF MAD area, anterolateral mitral annulus (substrate ablation) 90 54 9.7% → 4% decrease in PVC burden

*VA recurrence rates reported after single CA procedure.

LV, left ventricle; MAD, mitral annular disjunction; MR, mitral regurgitation; MV, mitral valve; MVP, mitral-valve prolapse; NSVT, non-sustained ventricular tachycardia; PPM, postero-medial papillary muscle; PVC, premature ventricular complex; VA, ventricular arrhythmia; VT, ventricular tachycardia.