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. 2023 Apr 17;14:1148954. doi: 10.3389/fendo.2023.1148954

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Copyright © 2023 Coulter, Greenway, Zhang, Ghosh, Coulter, James, He, Cusimano and Rebello

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NR and BC synergistically induce metabolism genes (A) mRNA levels (B) Western Blots of Protein levels (C) Protein levels were measured with β-actin as loading control. Adipocytes from three or more donors with obesity were treated for seven days. mRNA data are expressed as least squares means ± standard error. Synergy for mRNA was calculated as: sum of differences ((NR- Control) + (BC - Control)) vs (NRBC - Control). *p < 0.05 for synergy. NR, Naringenin; BC, beta carotene; NRBC, naringenin and beta carotene.