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. 2023 Apr 17;14:1148954. doi: 10.3389/fendo.2023.1148954

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Copyright © 2023 Coulter, Greenway, Zhang, Ghosh, Coulter, James, He, Cusimano and Rebello

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative receptor levels in white adipocytes (untreated) and NRBC-treated cells. (A) Low abundance (B) High abundance. Adipocytes from two donors with obesity were treated with cell medium (Control) or NRBC for seven days and transcript sequencing analysis was conducted. Data are expressed as mean normalized transcript counts (DEseq2). * indicates Padj< 0.002 for Control vs NRBC. β-adrenergic receptors (β1AR, β2AR, β3AR), G-protein coupled bile acid receptor (TGR5), Transient receptor potential cation channel subfamily M member 8 (TRPM8), Melanocortin-1 receptor (MC1R), Adenosine receptors A1 and A2B (ADORA1, ADORA2B), Natriuretic peptide receptors (NPR1, NPR3), G-protein coupled estrogen receptor 1 (GPER1), Parathyroid hormone receptor 1 (PTHR1), Growth hormone receptor (GHR).