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[Preprint]. 2023 Apr 17:2023.04.17.536878. [Version 1] doi: 10.1101/2023.04.17.536878

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Figure 7. — Similarity in microglia phenotypes from neonatal tamoxifen-induced Cx3cr1CreER(Litt) and Tgfbr2fl/fl;Cx3cr1Cre mice. (A) Transcriptomic phenotypes from P15 Cx3cr1CreER(Litt) (vehicle versus tamoxifen) and Tgfbr2;Cx3cr1Cre (Tgfbr2fl/+;Cre vs Tgfbr2fl/fl;Cre) mice showing changes in INF-signaling related, MgND/DAM, and hemeostatic gene expression. (B) Correlation between two data sets. (C) Brain sections from P15 Cx3cr1CreER(Litt) (vehicle versus tamoxifen) mice stained for DAPI (blue), IBA1 (green), P2ry12 (grey), pSMAD3 (red). Quantification of pSMAD3 mean fluorescence intensity in individual microglia from each group (D) shows no significant difference in pSMAD3 (P=0.0644; Students T-Test). Data were combined from 3 vehicle-treated and 4 tamoxifen-treated mice. Scale bar: 100 μm.