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[Preprint]. 2023 Apr 28:2023.04.18.537355. [Version 2] doi: 10.1101/2023.04.18.537355

Figure 6. PRODH is more abundant in the RPE/Cho and deletion of Prodh causes proline accumulation.

Figure 6.

(A) RPE/Cho has higher PRODH protein expression than RPE/Cho. β-tubulin is used as the loading control. (B) The relative protein expression level of PRODH in retina and RPE/Cho. ***P<0.001, N=4. (C-D) Prodh mutation causes the depletion of PRODH proteins in liver, retina and RPE/Cho in Prodh−/− mice. (E-H) Total abundance of proline in the liver, plasma, PRE/Cho and retina from Prodh−/− mice relative to those tissues from WT mice. ***P<0.001, N≥4.