Table 2:
Large T-LGL target tables.
| CA Nodes | ||
| Name | State | |
|
| ||
| S1P | OFF | |
|
| ||
| KRAS | OFF | |
|
| ||
| SPHK1 | OFF | |
|
| ||
| PDGFR | OFF | |
|
| ||
| DISC | ON | |
|
| ||
| Ceramide | ON | |
|
| ||
| GAP | ON | |
|
| ||
| (a) | ||
| CA Edges | ||
| Tail | Head | State |
|
| ||
| S1P | PDGFR | OFF |
|
| ||
| KRAS | MEK | OFF |
|
| ||
| JAK | STAT3 | OFF |
|
| ||
| SPHK1 | S1P | OFF |
|
| ||
| PDGFR | SPHK1 | OFF |
|
| ||
| DISC | Caspase | ON |
|
| ||
| DISC | MCL1 | ON |
|
| ||
| Ceramide | S1P | ON |
|
| ||
| GAP | KRAS | ON |
|
| ||
| (b) | ||
| FVS | ||
| Name | State | |
|
| ||
| TCR | Osc. | |
| ZAP70 | OFF | |
| GAP | OFF | |
| NFKB | ON | |
| IL2RB | ON | |
| IL2RA | OFF | |
| JAK | ON | |
| TBET | ON | |
| P2 | ON | |
| DISC | ON | |
| BID | ON | |
| S1P | OFF | |
| PDGF | OFF | |
| IL15 | ON | |
| Stimuli | ON | |
| Stimuli2 | OFF | |
| CD45 | OFF | |
| TAX | OFF | |
|
| ||
| (c) | ||
| SM | ||
| Name | State | |
|
| ||
| PDGFR | OFF | |
|
| ||
| S1P | OFF | |
|
| ||
| SPHK1 | OFF | |
|
| ||
| TBET | ON | |
| ERK | ON | |
| Ceramide | ON | |
|
| ||
| TBET | ON | |
| GRB2 | ON | |
| Ceramide | ON | |
|
| ||
| TBET | ON | |
| IL2RB | ON | |
| Ceramide | ON | |
|
| ||
| TBET | ON | |
| IL2RBT | ON | |
| Ceramide | ON | |
|
| ||
| TBET | ON | |
| KRAS | ON | |
| Ceramide | ON | |
|
| ||
| TBET | ON | |
| PI3K | ON | |
| MEK | ON | |
| Ceramide | ON | |
|
| ||
| (d) | ||
Here we list the control targets for the larger T-LGL model, where control sets are separated by double horizontal bars such that Table 2a contains seven singleton controls, Table 2b contains nine singleton controls, Table 2c contains one set of 18 controls (some of which are unnecessary), and Table 2d contains three singleton controls, five triple control sets, and one quadruple control set [2].