Recommendation | Who to test for monogenic diabetes |
---|---|
1 | All patients diagnosed with diabetes before the age of 6 months should be tested for monogenic forms of neonatal diabetes using the large-gene panel (Grade A). All patients diagnosed between 6 and 12 months should be tested for monogenic forms of neonatal diabetes using the large-gene panel (Grade B). No demonstrable yield of monogenic etiology to support reflexive genetic testing patients diagnosed with diabetes between 12-24 months. |
2 | Women with gestational diabetes and without obesity should be tested for GCK etiology (Grade A) |
3 | Those with persisting, mild hyperglycemia at any age, in the absence of obesity should be tested for GCK etiology (Grade A) |
4 | People without obesity under the age of 30 years who are either autoantibody negative and/or have retained C-peptide levels should be tested for monogenic diabetes using a large-gene panel (Grade A) |