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[Preprint]. 2023 Apr 19:2023.04.15.23288269. [Version 1] doi: 10.1101/2023.04.15.23288269
Recommendation Who to test for monogenic diabetes
1 All patients diagnosed with diabetes before the age of 6 months should be tested for monogenic forms of neonatal diabetes using the large-gene panel (Grade A). All patients diagnosed between 6 and 12 months should be tested for monogenic forms of neonatal diabetes using the large-gene panel (Grade B). No demonstrable yield of monogenic etiology to support reflexive genetic testing patients diagnosed with diabetes between 12-24 months.
2 Women with gestational diabetes and without obesity should be tested for GCK etiology (Grade A)
3 Those with persisting, mild hyperglycemia at any age, in the absence of obesity should be tested for GCK etiology (Grade A)
4 People without obesity under the age of 30 years who are either autoantibody negative and/or have retained C-peptide levels should be tested for monogenic diabetes using a large-gene panel (Grade A)