Figure 2.

CSF ANGPT2 level is elevated in MCI and correlates with markers of BBB leakiness, neuronal injury and neuroinflammation. A. Boxplot showing elevated ANGPT2 in MCI (n = 21) compared to cognitively unimpaired (CU) controls (n = 81). ANGPT2 level was did not differ significantly between AD (n = 19) and CU controls. B. CSF albumin levels are higher in MCI (p = 0.068) and significantly higher in AD (p = 0.0009) compared to CU controls. C. CSF ANGPT2 is positively correlated with CSF albumin level in the CU and MCI groups but not in the AD group. D. A summary of correlations between CSF ANGPT2 and CSF levels of disease pathology (Aβ40, Aβ42, t-tau, p-tau181); neuronal injury (neurogranin (ng) and alpha-synuclein (a-syn, neuro lament light (nfl) and S100) and neuroinflammation (GFAP, sTREM-2 and S100). * p < 0.05, **p < 0.01, *** p < 0.001