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. 2023 Apr 1;37(7-8):303–320. doi: 10.1101/gad.350078.122

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© 2023 Zacarías-Fluck et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Omomyc induces growth arrest in melanoma human cell lines in vitro. (A) Growth inhibition by transgenic Omomyc at 10 d by Crystal Violet staining. (B) Early effect of Omomyc on proliferation by cell count. (C) Colony formation assay. (D) Proliferation and cell death following Omomyc expression as a late event in A375 (top panels) and SkMel147 (bottom panels). (E) Cell cycle profiles during the first 4 d of Omomyc expression of A375 and SkMel147. Student's t-test of Omomyc-expressing samples to their relative controls (n = 3). (E) Relation between Omomyc expression and inhibition of proliferation. (F) MYC and Max expression at 7 d of Omomyc expression (representative image from triplicates). (*) P < 0.05, (**) P < 0.01, (***) P < 0.001, (****) P < 0.0001.