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. 2023 Apr 1;37(7-8):303–320. doi: 10.1101/gad.350078.122

Figure 4.

Figure 4.

Omomyc induces tumor regression and inhibition of metastases in human melanoma cell lines in vivo. Omomyc significantly impairs the growth of A375 (A) and SkMel147 (B), increasing the survival of tumor-bearing mice. Ki67 staining after 3 d of Omomyc expression in the tumor margin of A375 (C) and SkMel147 (D). Percentage of mice with spontaneous lung, liver, and lymph node metastases in A375 (E) and SkMel147 (F) models. Recurrence and lung metastases after tumor resection in A375 (G) and SkMel147 (H). (Veh) Vehicle, (Dox) doxyclycline.