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. 2023 Jan 10;119(4):982–997. doi: 10.1093/cvr/cvad005

Figure 2.

Figure 2

Metabolic reprogramming mediated by the SFA-EAA diet is associated with extensive changes in cardiac metabolite levels related to energy metabolism in sham- and TAC-operated mice. A and B: Principal component analysis (PCA) of metabolome data. Cardiac tissue (LV) was obtained from sham- (A) and TAC-operated (B) mice fed with SFA or SFA-EAA diet as in Figure 1A (n = 6 mice per group). (C and D) Volcano plot showing upregulated (red dots), downregulated (light-blue dots), and unchanged (grey dots) metabolites in LV of sham- (C) and TAC-operated (D) mice fed with SFA-EAA vs. SFA diet (n = 6 mice per group; P < 0.05). E and F: Biochemical classification of metabolites in LV of sham- (E) and TAC-operated (F) mice, shown as the number of metabolites for each class significantly modulated by SFA-EAA vs. SFA diet (n = 6 mice per group). Statistical analysis was performed with two-way ANOVA and an estimate of the false discovery rate (FDR) for multiple comparisons.