Figure 1. IGFBP7 in vascular ECs contributes to psoriasis.

IGFBP7^hi vascular ECs respond to JAK1/2-STAT1/3 signaling and overexpress and secrete IGFBP7 (i). IGFBP7 then binds to components of the glycocalyx, such as heparan sulfate (HS) (ii). The endothelial glycocalyx deteriorates, increasing vascular permeability. Degradation of the endothelial glycocalyx exposes various vascular adhesion molecules (VAM) (iii) to promote T cell adhesion and transmigration (iv).