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. 2023 May 2;18(5):e0273882. doi: 10.1371/journal.pone.0273882

Fig 2.

Fig 2

A-D. Immunohistochemistry of cytochrome C oxidase subunit III in young and old primate central (C) and peripheral (P) retina. Positive staining is present in the ganglion cell layer (GCL), Inner plexiform layer (IPL), inner nuclear layer (INL) and inner segment of the photoreceptor layer (PR). In both age groups, staining in the periphery appeared heavier than in the central retina. E-H. Images of photoreceptor inner segments at higher magnification. The peripheral images in both aged groups appeared to show heavier staining than central region. I. Western blot analysis confirming higher levels of expression of Complex III in the periphery of both age groups, but also revealing no consistent age related changes in expression in any retinal layer. N = 5 per group. Abbreviations: GCL, ganglion cell layer. IPL, inner plexiform layer. INL, inner nuclear layer. ILM, inner limiting membrane. OPL, outer plexiform layer. ONL, outer nuclear layer. ILM, outer limiting membrane. Photoreceptors, PR. Young centre, Y(C). Young periphery Y(P). Old centre, O(C). Old periphery, O(P). Statistical significance, * p<0.05. Uncropped images were not available for these data.