Table 4. Comparison of clinical symptoms across lesion severity categories.
| Total Lesion Severity Score | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Organ-Systems | Clinical Symptom | <25 | 25–99 | 100–499 | > = 500 | Fisher’s Exact Test/ Chi-square Test | Cochran-Armitage Trend Test | ||
| (N = 20) | (N = 58) | (N = 91) | (N = 47) | ||||||
| n (%) | n (%) | n (%) | n (%) | Adjusted P value | Raw P value | Adjusted P value | Raw P value | ||
| Chills | 10 (50.0) | 17 (29.3) | 41 (45.1) | 29 (61.7) | 0.2160 | 0.0098 | 0.4648 | 0.0227 | |
| General | Malaise | 18 (90.0) | 47 (81.0) | 73 (80.2) | 46 (97.9) | 0.2846 | 0.0136 | 1.0000 | 0.1678 |
| Sweats | 0 (0.0) | 7 (12.1) | 24 (26.4) | 12 (25.5) | 0.1821 | 0.0079 | 0.0899 | 0.0039 | |
| Skin/Derm | Rash | 16 (80.0) | 56 (96.6) | 90 (98.9) | 47 (100.0) | 0.0329 | 0.0013 | 0.0084 | 0.0003 |
| Lymphatics | Lymphadenopathy/Adenopathy | 13 (65.0) | 35 (60.3) | 43 (47.3) | 33 (70.2) | 1.0000 | 0.0540 | 1.0000 | 0.8442 |
| Conjunctiva redness, Eye pain, Eye discharge, etc. | 0 (0.0) | 5 (8.6) | 6 (6.6) | 9 (19.1) | 1.0000 | 0.0559 | 0.4648 | 0.0221 | |
| Ear Pain | 0 (0.0) | 4 (6.9) | 6 (6.6) | 5 (10.6) | 1.0000 | 0.5886 | 1.0000 | 0.1743 | |
| HEENT | Mouth/Throat Lesions | 1 (5.0) | 8 (13.8) | 24 (26.4) | 20 (42.6) | 0.0265 | 0.0010 | 0.0019 | < .0001 |
| Nasal Discharge/Congestion | 3 (15.0) | 11 (19.0) | 30 (33.0) | 23 (48.9) | 0.0952 | 0.0040 | 0.0084 | 0.0003 | |
| Sore Throat | 15 (75.0) | 42 (72.4) | 71 (78.0) | 41 (87.2) | 1.0000 | 0.2968 | 1.0000 | 0.1009 | |
| Visual Changes | 0 (0.0) | 1 (1.7) | 3 (3.3) | 1 (2.1) | 1.0000 | 1.0000 | 1.0000 | 0.5505 | |
| Cardiovascular | Chest Pain | 1 (5.0) | 3 (5.2) | 5 (5.5) | 2 (4.3) | 1.0000 | 1.0000 | 1.0000 | 0.8892 |
| Lungs | Cough | 8 (40.0) | 24 (41.4) | 43 (47.3) | 29 (61.7) | 1.0000 | 0.1676 | 0.6651 | 0.0391 |
| Shortness of Breath | 1 (5.0) | 1 (1.7) | 6 (6.6) | 7 (14.9) | 1.0000 | 0.0719 | 0.4648 | 0.0241 | |
| Abdominal Pain | 6 (30.0) | 11 (19.0) | 21 (23.1) | 12 (25.5) | 1.0000 | 0.7069 | 1.0000 | 0.8845 | |
| Anorexia | 7 (35.0) | 22 (37.9) | 44 (48.4) | 35 (74.5) | 0.0199 | 0.0007 | 0.0051 | 0.0002 | |
| Gastrointestinal | Diarrhea | 0 (0.0) | 1 (1.7) | 7 (7.7) | 2 (4.3) | 1.0000 | 0.3476 | 1.0000 | 0.2239 |
| Dysphagia | 2 (10.0) | 11 (19.0) | 25 (27.5) | 16 (34.0) | 1.0000 | 0.1235 | 0.3466 | 0.0158 | |
| Vomiting | 0 (0.0) | 1 (1.7) | 7 (7.7) | 5 (10.6) | 1.0000 | 0.1553 | 0.4648 | 0.0238 | |
| Hematologic | Bleeding, Active, Various Sites | 0 (0.0) | 1 (1.7) | 3 (3.3) | 2 (4.3) | 1.0000 | 0.9282 | 1.0000 | 0.2635 |
| Petechiae | 0 (0.0) | 0 (0.0) | 1 (1.1) | 1 (2.1) | 1.0000 | 0.7727 | 1.0000 | 0.2425 | |
| Back Pain | 3 (15.0) | 4 (6.9) | 12 (13.2) | 6 (12.8) | 1.0000 | 0.5600 | 1.0000 | 0.6511 | |
| Joint Pain | 3 (15.0) | 2 (3.4) | 7 (7.7) | 8 (17.0) | 1.0000 | 0.0648 | 1.0000 | 0.2154 | |
| Musculoskeletal | Muscle Pain | 0 (0.0) | 6 (10.3) | 5 (5.5) | 4 (8.5) | 1.0000 | 0.4428 | 1.0000 | 0.6447 |
| Neck Stiffness | 1 (5.0) | 0 (0.0) | 5 (5.5) | 3 (6.4) | 1.0000 | 0.1961 | 1.0000 | 0.2344 | |
| Neurologic | Dizziness | 0 (0.0) | 0 (0.0) | 3 (3.3) | 0 (0.0) | 1.0000 | 0.4998 | 1.0000 | 0.6454 |
| Headache | 4 (20.0) | 13 (22.4) | 22 (24.2) | 12 (25.5) | 1.0000 | 0.9705 | 1.0000 | 0.5860 | |
Total lesion severity score is total number of lesions present on admission day. Differences between categories tested by Fisher exact test or Chi-square test with stepdown Bonferroni correction. Trend (decreasing or increasing) across categories tested by Cochran-Armitage Trend Test with stepdown Bonferroni correction. Significant differences were bolded (adjusted p value ≤ 0.05)