Table 2.

Stratified analysis of risk of retinal vascualr occlusion exposed to COVID-19 vaccines compared with unvaccinated individuals in 2 years.

	Number of events
	Vaccinated	Unvaccinated	HR and 95% Cl
Age 18–64	506,701	506,701
Retinal vascular occlusionb	415	240	1.87 (1.58–2.19)
BRAO	95	63	1.65 (1.19–2.28)
BRVO	174	86	2.21 (1.69–2.87)
CRAO	45	34	1.47 (0.93–2.31)
CRVO	156	78	2.19 (1.65–2.88)
Age ≥ 65	236,804	236,804
Retinal vascular occlusionb	1108	520	2.37 (2.12–2.62)
BRAO	251	140	2.07 (1.67–2.54)
BRVO	443	180	2.70 (2.26–3.21)
CRAO	136	89	1.74 (1.32–2.28)
CRVO	390	169	2.55 (2.12–3.05)
Female	437,682	437,682
Retinal vascular occlusionb	782	359	2.33 (2.05–2.64)
BRAO	168	92	2.02 (1.56–2.61)
BRVO	332	133	2.64 (2.15–3.23)
CRAO	99	58	1.88 (1.34–2.60)
CRVO	272	115	2.54 (2.04–3.16)
Male	302,269	302,269
Retinal vascular occlusionb	731	328	2.40 (2.10–2.73)
BRAO	178	92	2.17 (1.67–2.80)
BRVO	277	104	2.81 (2.23–3.52)
CRAO	87	55	1.69 (1.20–2.37)
CRVO	266	104	2.79 (2.21–3.50)
White	545,223	545,223
Retinal vascular occlusionb	1146	546	2.31 (2.08–2.55)
BRAO	278	149	2.12 (1.72–2.59)
BRVO	465	179	2.79 (2.34–3.31)
CRAO	135	86	1.78 (1.35–2.34)
CRVO	396	175	2.52 (2.10–3.01)
African American	89,833	89,833
Retinal vascular occlusionb	218	118	2.05 (1.63–2.56)
BRAO	40	25	1.85 (1.11–3.07)
BRVO	84	42	2.18 (1.50–3.16)
CRAO	37	19	2.14 (1.22–3.73)
CRVO	83	41	2.28 (1.56–3.31)
Asian	26,080	26,080
Retinal vascular occlusionb	40	16	2.62 (1.46–4.68)
BRAO	<10a	<10a	1.93 (0.46–8.11)
BRVO	22	<10a	2.84 (1.25–6.39)
CRAO	<10a	<10a	3.69 (0.41–33.00)
CRVO	<10a	<10a	1.78 (0.64–4.93)

^aDue to policy of TriNetX, any number less than 10 will be automatically assigned as <10.

^bThe diagnosis of retinal vascular occlusion was determined by its diagnostic codes, rather than by the sum of its subtypes.

HR Hazard ratio, 95% CI 95% confidence interval.