Nicotine exposure leads to changes in WAT. These changes include decreased lipogenesis, serum levels of ω−6 fatty acids, and oxylipins 9- and 13-HODE, as well as increased adipose tissue lipolysis, fatty acid synthesis, whole body inflammation, GLUT2 and GLUT4 expression, IL-10 levels, and activation of resident macrophages. Created with BioRender.com.