TABLE 4.
Presence of macroscopic tuberculous lymph node lesions in cattle following challenge with virulent M. bovis (experiment 3)
| Group | No. of cattle with lesioned lymph nodes/total no.a
|
No. of lesioned lymph nodes/animalb | Lymph node bacterial countsc | % of thoracic lymph nodes M. bovis culture positive | |
|---|---|---|---|---|---|
| All sites | Outside thoracic cavity | ||||
| Control (MPL) | 11/11 | 1/11 | 3.18 ± 0.38 | 2.42 ± 0.14 | 84 |
| BCG vaccinated | 7/10 | 0/10 | 1.20 ± 0.33* | 1.86 ± 0.18‡ | 53* |
| High-dose CFP–IL-2 | 11/11 | 5/11§ | 3.36 ± 0.28 | 2.53 ± 0.12 | 73 |
| Low-dose CFP–IL-2 | 4/4 | 0/4 | 3.5 ± 0.29 | 2.41 ± 0.14 | 81 |
a
Macroscopic tuberculous lesions were observed in the thoracic, head, and mesenteric lymph nodes. §, significantly greater than the control and BCG-vaccinated groups (P < 0.05).
b
Mean number of lesioned lymph nodes per animal ± SE. *, significantly less than the control (MPL adjuvant only) group (P < 0.05).
c
Geometric mean for bacterial counts (log10 CFU per gram of tissue) ± SE. ‡, significantly less than the high-dose CFP–IL-2 group (P < 0.05).