Figure 6.

Microscopic image of rat pancreatic islets. (a) Normal pancreatic cells, (b) disease showing extensive damage to the islet of Langerhans and hemorrhagic (H) condition, (c) treatment with 5 mg/kg of 1,3,4-oxadiazole derivative showed hemorrhagic cells, (d) treatment with 10 mg/kg of 1,3,4-oxadiazole derivative showed vacuolization of β cells of islets of Langerhans, hemorrhage (H), (e) treatment with 15 mg/kg of 1,3,4-oxadiazole derivative showed hypertrophy and vacuolization of β cells of islets of Langerhans, (f) treatment with glimepiride showed little recovery of cells but still hemorrhage (H), and (g) treatment with acarbose showed hemorrhagic condition in β cells.