Fig. 2. Amyloid-PET evolution with respect to Braak stage.

a, Average [¹⁸F]AZD4694 amyloid-PET SUVRs across the whole brain grouped according to PET-based tau Braak stage. Each set of images represents the average amyloid-PET of individuals grouped according to their tau-PET scan. b, Neocortical amyloid-PET uptake increases and then plateaus with advancing Braak stage. The dashed line indicates a previously validated threshold for amyloid-PET positivity. Individuals at PET-based Braak stage 0 were often amyloid-β negative. Neocortical amyloid-PET SUVRs were higher at PET-based Braak stages I and II, although both stages were compatible with amyloid-β positivity and amyloid-β negativity. Individuals at Braak stage III and higher were almost exclusively amyloid-β positive. From Braak stage IV onwards, a plateau of amyloid-PET uptake was observed. Group means are represented by shapes, and error bars represent s.d. Summary statistics for all amyloid-PET comparisons are reported in Supplementary Table 2; two-sided ANOVA with Dunnett’s correction for multiple comparisons (n = 324).