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. 2022 Apr 25;2(6):526–535. doi: 10.1038/s43587-022-00204-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Top: proportion of cases with established focal cortical presentations of AD that fit (turquoise) and do not fit (purple) with the Braak staging system. Middle: Tau-PET images of representative Braak-discordant cases are displayed in the middle. Bottom: [¹⁸F]MK6240 Tau-PET uptake in each Braak stage of discordant case presented. Absence of tau abnormality in Braak stage II (entorhinal cortex and hippocampus) was the most common reason for Braak discordance in atypical focal cortical presentations of AD, and may be associated with MTL-sparing AD. Relative tau-PET uptake within certain Braak stages may be associated with relative predominance of specific cognitive impairment and clinical presentation. Individuals with nonamnestic dementia phenotypes were included in the main analyses. The individual focal cortical syndrome cases displayed above were classified as Braak stage V.