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. 2023 Mar 16;24(5):827–840. doi: 10.1038/s41590-023-01468-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a-c, Representative histograms of Cre intracellular expression in BM progenitors, as in Extended Data Fig. 1b,c (a), in blood leukocytes, as in Extended Data Fig. 1d (b), and in small and large peritoneal macrophages (SPM and LPM, respectively), Kupffer cells (KC), red pulp splenic macrophages (RPM), small intestinal (SI) and colon (C) lamina propria macrophages (LPM), as in Extended Data Fig. 1e-i (c) from Tmem119^+/+ (blue) and Tmem119^Cre/+ (red) mice. d, Flow cytometry gating strategy to show brain FSC^loCD45^intF4/80⁺CD11b⁺CD64⁺Ly6C⁻ microglia. e, Representative histograms of Cre intracellular protein expression in microglia from Tmem119^+/+ (blue) and Tmem119^Cre/+ (red) mice. f-h, Bar graphs showing normalized Cre expression in the indicated cell populations from the BM (f) and the blood (g), and in tissue RTM (h). Data show mean ± SEM (n = 4 mice per group). In h, P values compare microglia vs. every other population and were calculated using a one-way analysis of variance (ANOVA) with Tukey’s post hoc tests. Raw data and P values are provided as a source data file. ^****, P < 0.0001. CDP, common plasmacytoid and dendritic cell progenitor; cMoP, common monocyte progenitor; CMP, common myeloid progenitor; GMP, granulocyte-monocyte progenitor; GP, granulocyte progenitor; LSK, lineage(Lin)⁻Sca-1⁺cKit⁺ multipotent progenitor; MDP, monocyte-dendritic cell progenitor.

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