Extended Data Fig. 9. Single consensus coabundance network of taxa combining all the microbiomes from younger participants with age < 60 years from the 12 individual studies.
We selected a set of 112 species that are commonly identified in both 16S and Shotgun datasets. Associations between the centered-log-ratio transformed abundances of species pair were individually computed within each study using robust linear regression models. Results of the individual robust linear regression models were then collated using Random Effect models to compute summarized association statistics. For each species, the summarized association p-values for every other were then FDR-corrected and those species having a stringent threshold of Q < = 0.001 and an overall summarized association estimate of greater than 0 were determined to have co-abundant relationship with it. The species-level nodes belonging to the different species groups are filled in different colors, namely green for Kendall Uniqueness negative, red for Kendall Uniqueness positive and light blue for other species. Species-level taxa that were either elevated or depleted in multiple scenarios of unhealthy young are shown in deep pink and dark blue, respectively.