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. 2023 Mar 13;3(4):418–435. doi: 10.1038/s43587-023-00379-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — (a) Diversity estimation of CD4 TCR repertoire in young (n = 3) and old (n = 3) donors before and after vaccination (7 days after the second dose). Higher value for greater diversity. *: p < 0.05; **: p < 0.01; ***: p < 0.001; ns: not significant. Wilcoxon Rank Sum test (two-sided). (b) Clonotype expansion of the top 40 CDR3 clonotypes for CD8 TCRα, CD4 TCRα, CD4 TCRβ for young and old groups before and after vaccination (7 days after the second dose).