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. 2023 Mar 13;3(4):418–435. doi: 10.1038/s43587-023-00379-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (a) Comparison of SARS-CoV-2 neutralizing antibody titer between young and old group on Day 7 (top row) and Day 50 (bottom row) after receiving the second dose of inactivated SARS-CoV-2 vaccine. Young: 18-30 years old, n = 121 for Day 7 after the second dose, n = 44 for Day 50 after the second dose; Old: 60-85 years old, n = 48 for both Day 7 and Day 50 after the second dose. Each dot represents a single individual. Data are summarized as mean ± SD. P-values are determined by two-sided T-test. (b) SARS-CoV-2 neutralizing IgG, total IgG and IgM quantification by ELISA. The data are presented for the young (top panel) and old (bottom panel) participants separated by gender. The regression line is shown in red for female and blue for male, with shading representing the 95% confidence interval. Young: 18-30 years old, 81 females and 40 males; Old: 60-85 years old, 27 females and 21 males. D14: 14 days after the 1st injection; D35: 35 days after the 1st injection, which was 7 days after the 2nd dose; D78: 78 days after the 1st injection, which was 50 days after the 2nd dose. Each dot represents a single individual. Two-sided T-test was used for assessing the significance of difference between two gender groups at each time point.