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. 2022 Sep 20;2(9):837–850. doi: 10.1038/s43587-022-00281-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Scatter-plot comparison of synapse proteomes from 9 months old P301S versus WT mice (x axis) and AD versus control patients (y axis)³⁹. Only orthologous protein pairs that were present in both datasets are shown. Of the 315 proteins that were significantly increased in P301S versus WT mice (P < 0.05, FC > 2) regardless of C1q genotype), 175 were increased in patients with AD versus controls, including the labeled proteins. Overall correlation of 0.34. NC, no change. b, Levels of total and processed C4 and Factor B and processed Bb fragment in CSF from controls and patients wth AD. Each dot represents the values from one individual. CSF samples from 15 controls and 14 patients with AD were analyzed (the same patients identified in previous works⁴; cohort 1). Data were analyzed by two-tailed unpaired Student’s t-test. All data are presented as mean ± s.e.m.

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