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. 2022 Aug 15;2(8):742–755. doi: 10.1038/s43587-022-00263-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a Correlation coefficient matrix of metrics from nuclei. b Contour distribution of aspect versus area of nuclei for individuals under 40. c Contour distribution of aspect versus area of nuclei for individuals over 60. d Volcano plot of conditions based on IR senescence residuals and p values (two-sided Fisher’s exact test). e Volcano plot of conditions based on RS senescence probability residuals and p values (two-sided Fisher’s exact test). f Volcano plot of conditions based on doxorubicin senescence probability residuals and p values (two-sided Fisher’s exact test). g Volcano plot of conditions based on ATV/r senescence probability residuals and p values (two-sided Fisher’s exact test). h Volcano plot of conditions based on antimycin-A senescence probability residuals and p values (two-sided Fisher’s exact test). i Volcano plot of conditions based on probability of unified senescence probability residuals and p values (two-sided Fisher’s exact test). j Volcano plot of conditions based on percent IR senescence residuals and p values (two-sided Fisher’s exact test). k Volcano plot of conditions based on percent RS senescence residuals and p values (two-sided Fisher’s exact test). l Volcano plot of conditions based on percent doxorubicin senescence residuals and p values (two-sided Fisher’s exact test). m Volcano plot of conditions based on percent ATV/r senescence residuals and p values (two-sided Fisher’s exact test). n Volcano plot of conditions based on percent antimycin-A senescence residuals and p values (two-sided Fisher’s exact test). o Volcano plot of conditions based on percent unified senescence residuals and p values (two-sided Fisher’s exact test).